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Literature summary for 3.4.21.B10 extracted from
- Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients (2012), Biol. Chem., 393, 391-401.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | stromal cell-associated expression of kallikrein-related peptidase 6 indicates poor prognosis of ovarian cancer patients | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antithrombin III | most efficient endogenous inhibitor | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 31000 | - |
x * 43000, glycosylated enzyme, SDS-PAGE, x * 31000, deglycosylated enzyme, SDS-PAGE | Homo sapiens |
| 43000 | - |
x * 43000, glycosylated enzyme, SDS-PAGE, x * 31000, deglycosylated enzyme, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q92876 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | the enzyme is N-glycosylated at Asn134 | Homo sapiens |
| proteolytic modification | the enzyme performs autoproteolytic activation | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | high enzyme expression level | Homo sapiens | - |
| breast | - |
Homo sapiens | - |
| colon | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| additional information | immunohistochemic enzyme tissue expression analysis, overview | Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
| ovary cancer cell | the enzyme is up-regulated in ovarian cancer | Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| prostate | - |
Homo sapiens | - |
| skeletal muscle | - |
Homo sapiens | - |
| skin | - |
Homo sapiens | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 43000, glycosylated enzyme, SDS-PAGE, x * 31000, deglycosylated enzyme, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| kallikrein 6 | - |
Homo sapiens |
| kallikrein-related peptidase 6 | - |
Homo sapiens |
| KLK6 | - |
Homo sapiens |
| protease M | - |
Homo sapiens |
| zyme | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the enzyme is up-regulated in ovarian cancer | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | The enzyme plays a crucial role in ovarian cancer. Regulation of KLK6 activity is mediated mainly through (auto-)proteolytic activation or inactivation with most effi cient inhibition is achieved by endogenous antithrombin III | Homo sapiens |
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